Design and synthesis of an orally active biologic based on cyclic ω-conotoxin MVIIA-GS.
MVIIA is a peptide isolated from cone snail venom. It is a potent inhibitor of N-type voltage-gated calcium channels on presynaptic neurons, preventing release of neurotransmitters for pain signal transmission. Its synthetic form Ziconotide has been approved for clinical therapy but can only be admi...
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| 格式: | Final Year Project |
| 語言: | English |
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2011
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| 在線閱讀: | http://hdl.handle.net/10356/44537 |
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