Bcl-2 phosphorylation and implications in apoptosis in cancer cells

• Main Author: Xia, Yan
• Other Authors: Yoon Ho Sup
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/44593
• Institution: Nanyang Technological University

Bcl-2 is the central regulator in apoptosis. Structural studies of Bcl-2 reveal a flexible loop flanking the Bcl-2 homology domain 3 (BH3) and BH4. In response to external stimuli, several kinases phosphorylate the loop of Bcl-2. Phosphorylation on Bcl-2 has been thought to affect the protein’s acti...