Study of biomarkers in the epithelial-mesenchymal transition of triple negative breast cancers and their associations with clinicopathological parameters
Triple Negative Breast cancer (TNBC) is a newly studied subtype of breast cancer. Existing literature demonstrates that as cancer advances, the tumor cells will undergo epithelial-mesenchymal transition (EMT) to form secondary tumors at distant site. E-cadherin and Vimentin are biomarkers for epithe...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/10356/45029 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Triple Negative Breast cancer (TNBC) is a newly studied subtype of breast cancer. Existing literature demonstrates that as cancer advances, the tumor cells will undergo epithelial-mesenchymal transition (EMT) to form secondary tumors at distant site. E-cadherin and Vimentin are biomarkers for epithelial and mesenchymal states respectively. β-catenin is involved in maintaining stable epithelial complex with E-cadherin and in signalling pathway implicated in tumorogenesis. |
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