Pharmacogenetics of the prostaglandin-endoperoxide synthase 2 (PTGS-2) 5' and 3' untranslated regions in three distinct Asian populations.

• Main Author: Yip, Fong Ee.
• Other Authors: Kristen Elizabeth Sadler
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/45272
• Institution: Nanyang Technological University

Cyclooxygenase-2 (COX-2) is an enzyme induced in response to mitogens, tumour promoters, and cytokines. Gene expression of COX-2 is found to be upregulated in solid tumours. Polymorphisms in regulatory regions of PTGS-2 encoding COX-2 were demonstrated to influence COX-2 expression levels and alter...