Increasing in vivo iron loading of archaeoglobus fulgidus ferritin (afftn) transformed E.coli by overexpressing the ferrous transporter, FeoB

• Main Author: Tan, Ker Jia.
• Other Authors: Lim Sierin
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Engineering::Chemical engineering::Biotechnology
• Online Access: http://hdl.handle.net/10356/45282
• Institution: Nanyang Technological University

Research has proven iron-loaded Archaeoglobus fulgidus ferritin (AfFtn) as a good T2 MRI contrast agent and that higher concentrations of iron in iron-loaded AfFtn enhanced T2 imaging contrasts. Works on increasing in vivo AfFtn iron loading using E. coli as a biofactory have been performed by incre...