Highly stereoselective synthesis of tetrahydro-1,2-oxazines and bicyclic isoxazolidines from nitroso benzenes and 5-alkenylaldehydes
In 2000, List and co-workers firstly reported that L-proline was an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone an a variety of aldehydes, with yields and enantioselectivities from moderate to good. This discovery has initiated the explosive growth of resea...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2011
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| Online Access: | http://hdl.handle.net/10356/46316 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | In 2000, List and co-workers firstly reported that L-proline was an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone an a variety of aldehydes, with yields and enantioselectivities from moderate to good. This discovery has initiated the explosive growth of research activities in organic chemistry. Now asymmetric organo-catalysis in which small chiral organic molecules act as catalytically active species, emerged as powerful synthetic tool and are complementary to transition metal based catalysis and biocatalysis in asymmetric synthesis. |
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