Studies of intrinsically curved and forcibly curved DNA as well as their interactions with topological enzymes

• Main Author: Yang, Zhaoqi
• Other Authors: School of Physical and Mathematical Sciences
• Format: Theses and Dissertations
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/48080
• Institution: Nanyang Technological University

Topological enzymes, both type I and type II topoisomerases, are not only essential for the processes of cell growth, but also for their effect on altering the geometrical conformations of DNA. It has been shown that Human topoisomerase I (hTopo I), belonging to the type I subfamily, binds to DNA in...