Studies of intrinsically curved and forcibly curved DNA as well as their interactions with topological enzymes

• المؤلف الرئيسي: Yang, Zhaoqi
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2012
• الموضوعات: DRNTU::Science::Chemistry::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/48080

Topological enzymes, both type I and type II topoisomerases, are not only essential for the processes of cell growth, but also for their effect on altering the geometrical conformations of DNA. It has been shown that Human topoisomerase I (hTopo I), belonging to the type I subfamily, binds to DNA in...