8-oxoguanine : an effective Z-DNA stabilizer.

Poly d(CG)’s conformations transitions have been the topic for many studies. It has been reported that, at low – salt conditions, most of the conformations are in right - handed B forms, while left – handed Z form dominates the high – salt regime. However, Z DNA can be stabilized under low salt conc...

Full description

Saved in:
Bibliographic Details
Main Author: Quang, Tran Minh Nhat.
Other Authors: Phan Anh Tuan
Format: Final Year Project
Language:English
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/10356/49107
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-49107
record_format dspace
spelling sg-ntu-dr.10356-491072023-02-28T23:13:51Z 8-oxoguanine : an effective Z-DNA stabilizer. Quang, Tran Minh Nhat. Phan Anh Tuan School of Physical and Mathematical Sciences DRNTU::Science::Biological sciences::Biophysics Poly d(CG)’s conformations transitions have been the topic for many studies. It has been reported that, at low – salt conditions, most of the conformations are in right - handed B forms, while left – handed Z form dominates the high – salt regime. However, Z DNA can be stabilized under low salt concentration by many factors. Various Z – DNA stabilizers have been found, while many more are being studied. 8 – oxoguanine is a very common product of DNA oxidation process during aerobic respiration. 8 – oxoguanine has shown the potential for genetic mutation, cancer possibility, aging. Although DNA with 8 – oxoguanine appears to possess similar structure to natural DNA at low temperature, it has been reported that the environment is significantly changed by the modified base. Hence, the deeper understanding in the influence of 8 – oxoguanine to DNA secondary’s structure is necessary. Many modified guanine bases have shown the ability to stabilized Z form DNA under low-salt conditions. Regarding the need of studying 8 – oxoguanine, it is possible that 8 – oxoguanine can be an effective Z DNA stabilizer. Bachelor of Science in Physics 2012-05-15T01:41:38Z 2012-05-15T01:41:38Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/49107 en 69 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Biophysics
spellingShingle DRNTU::Science::Biological sciences::Biophysics
Quang, Tran Minh Nhat.
8-oxoguanine : an effective Z-DNA stabilizer.
description Poly d(CG)’s conformations transitions have been the topic for many studies. It has been reported that, at low – salt conditions, most of the conformations are in right - handed B forms, while left – handed Z form dominates the high – salt regime. However, Z DNA can be stabilized under low salt concentration by many factors. Various Z – DNA stabilizers have been found, while many more are being studied. 8 – oxoguanine is a very common product of DNA oxidation process during aerobic respiration. 8 – oxoguanine has shown the potential for genetic mutation, cancer possibility, aging. Although DNA with 8 – oxoguanine appears to possess similar structure to natural DNA at low temperature, it has been reported that the environment is significantly changed by the modified base. Hence, the deeper understanding in the influence of 8 – oxoguanine to DNA secondary’s structure is necessary. Many modified guanine bases have shown the ability to stabilized Z form DNA under low-salt conditions. Regarding the need of studying 8 – oxoguanine, it is possible that 8 – oxoguanine can be an effective Z DNA stabilizer.
author2 Phan Anh Tuan
author_facet Phan Anh Tuan
Quang, Tran Minh Nhat.
format Final Year Project
author Quang, Tran Minh Nhat.
author_sort Quang, Tran Minh Nhat.
title 8-oxoguanine : an effective Z-DNA stabilizer.
title_short 8-oxoguanine : an effective Z-DNA stabilizer.
title_full 8-oxoguanine : an effective Z-DNA stabilizer.
title_fullStr 8-oxoguanine : an effective Z-DNA stabilizer.
title_full_unstemmed 8-oxoguanine : an effective Z-DNA stabilizer.
title_sort 8-oxoguanine : an effective z-dna stabilizer.
publishDate 2012
url http://hdl.handle.net/10356/49107
_version_ 1759854891212210176