Role of cargo receptors in Synphilin-1 mediated selective autophagy of protein aggregates.

• Main Author: Lee, Karen Feng Yi.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2012
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/49281
• Institution: Nanyang Technological University

The ANK-1 domain of synphilin-1 has been recently identified to able to impart autophagic clearance signals to certain disease-linked protein inclusions that were previously resistant to clearance by autophagy. To examine whether ANK1 cooperates with known cargo adaptors, p62 and NBR1, in mediating...