Role of cargo receptors in Synphilin-1 mediated selective autophagy of protein aggregates.

• Main Author: Tan, Charlene Yan Ning.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2012
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/49475
• Institution: Nanyang Technological University

Aggrephagy is a macroautophagy pathway that selectively degrades protein aggregates. Cargo adaptor proteins, NBR1 and p62, have been found to selectively sequester protein aggregates into autophagosome for lysosomal degradation via autophagic pathway. Moreover, the Sphilin-1 protein contains an ANK1...