Characterization of mechanism of inhibition of dengue virus NS5 methyltransferase by hit/lead compounds generated from drug discovery programs.
The N-terminal domain of the flavivirus NS5 protein functions as a methyltransferase (MTase). It sequentially methylates the N7 and 2’-O positions of the viral RNA cap structure (GpppA → 7meGpppA → 7meGpppA2’-O-me). It is currently unknown how the MTase catalyzes these distinct sequential methylatio...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2012
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| Online Access: | http://hdl.handle.net/10356/50717 |
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| Institution: | Nanyang Technological University |
| Language: | English |