Characterization of pellino1 and pellino2 in toll-like receptor signaling

• Main Author: Dai, Liang
• Other Authors: -
• Format: Theses and Dissertations
• Language: English
• Published: Nanyang Technological University 2012
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/50864
• Institution: Nanyang Technological University

Pellino family proteins were first identified as interacting partners with kinase IRAK1 in TLR/IL-1R pathway. There are three Pellino isoforms in human cells, termed Pellino1, Pellino2 and Pellino3. They contain a FHA and a RING domain in the N- and C-terminus regions respectively. The major varianc...