Analyzing the roles of human U1 snRNA variants in pre-mRNA processing.

• 主要作者: Goh, Eling.
• 其他作者: Fabrizio Galli
• 格式: Final Year Project
• 語言: English
• 出版: 2013
• 主題: DRNTU::Science::Biological sciences::Genetics
• 在線閱讀: http://hdl.handle.net/10356/52293
• 機構: Nanyang Technological University

Splicing and polyadenylation are two essential steps in pre-mRNA processing. During splicing, U1 snRNP binds to a diversity of 5’ splice sites (5’ss) with its 5’ end. However, there remains a number of 5’ss that could not be bound optimally by the U1 snRNP. Very recently, U1 snRNA class I pseudogene...