Analyzing the roles of human U1 snRNA variants in pre-mRNA processing.

• Main Author: Goh, Eling.
• Other Authors: Fabrizio Galli
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/52293
• Institution: Nanyang Technological University

Splicing and polyadenylation are two essential steps in pre-mRNA processing. During splicing, U1 snRNP binds to a diversity of 5’ splice sites (5’ss) with its 5’ end. However, there remains a number of 5’ss that could not be bound optimally by the U1 snRNP. Very recently, U1 snRNA class I pseudogene...