Characterizing drug resistance in hypoxia-adapted chronic myeloid leukaemia cells.

• المؤلف الرئيسي: Muhammad Rauzan Rafman.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/52743

The development of tyrosine kinase inhibitors (TKI) has improved treatment of chronic myeloid leukaemia (CML) but resistance is observed in patients with advanced-stage CML. Second-generation TKIs overcome most resistance mechanisms but are ineffective against quiescent and hypoxic CML stem cells. M...