Characterizing drug resistance in hypoxia-adapted chronic myeloid leukaemia cells.
The development of tyrosine kinase inhibitors (TKI) has improved treatment of chronic myeloid leukaemia (CML) but resistance is observed in patients with advanced-stage CML. Second-generation TKIs overcome most resistance mechanisms but are ineffective against quiescent and hypoxic CML stem cells. M...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/10356/52743 |
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| Institution: | Nanyang Technological University |
| Language: | English |