Study and characterization of the interactions of the recently discovered functional amyloid fibril, FapC with signaling molecules and potential inhibitors with three biosensors : Biacore™ T200, EnSpire® and LigandTracer®.

• Main Author: Gea, Chong Jin.
• Other Authors: Susana Geifman Shochat
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria; DRNTU::Science::Biological sciences::Biophysics
• Online Access: http://hdl.handle.net/10356/52908
• Institution: Nanyang Technological University

Pseudomonas spp. biofilms typically grow in aqueous environments of high shear and flow rate. Despite the conditions, the biofilms are able to retain signaling molecules that are involved in QS and biofilm development through EPS. While it is unknown how these molecules bind, it has been proposed th...