Site-directed mutagenesis of p97/VCP to gain insight on the role of ATP binding to D1 domain affecting adaptor protein selectivity.
p97/VCP is a homohexameric AAA-ATPase associated with diverse cellular activities such as DNA repair and endoplamic reticulum-associated degradation (ERAD). The diversity of its functions lies within the interaction with different adaptor proteins such as p47 and Ufd1/Npl4 (UN) heterodimer. By bindi...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2013
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| Online Access: | http://hdl.handle.net/10356/52920 |
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| Institution: | Nanyang Technological University |
| Language: | English |