Site-directed mutagenesis of p97/VCP to gain insight on the role of ATP binding to D1 domain affecting adaptor protein selectivity.

• Main Author: Rizal Ismail.
• Other Authors: Susana Geifman Shochat
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/52920
• Institution: Nanyang Technological University

p97/VCP is a homohexameric AAA-ATPase associated with diverse cellular activities such as DNA repair and endoplamic reticulum-associated degradation (ERAD). The diversity of its functions lies within the interaction with different adaptor proteins such as p47 and Ufd1/Npl4 (UN) heterodimer. By bindi...