The identification of cis-regulatory elements of runx3

The identification of cis-regulatory elements of runx3

The RUNX3 gene is essential for the development of multiple cell lineages and is frequently involved in a variety of cancers and immunological diseases. Despite such frequent association with human diseases, the transcriptional regulation of Runx3 remains elusive. Owing to the huge ~350 kb Runx3 loc...

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Main Author: Nah, Giselle Sek Suan
Other Authors: School of Biological Sciences
Format: Theses and Dissertations
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:http://hdl.handle.net/10356/53732
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-537322023-02-28T18:44:29Z The identification of cis-regulatory elements of runx3 Nah, Giselle Sek Suan School of Biological Sciences Motomi Osato DRNTU::Science::Biological sciences The RUNX3 gene is essential for the development of multiple cell lineages and is frequently involved in a variety of cancers and immunological diseases. Despite such frequent association with human diseases, the transcriptional regulation of Runx3 remains elusive. Owing to the huge ~350 kb Runx3 locus and complexity of the use of two alternate promoters for transcription, the search for regulatory regions outside the immediate promoters by traditional methods such as DNase I hypersensitive assay, proved to be a daunting task. ​Doctor of Philosophy (SBS) 2013-06-07T02:37:41Z 2013-06-07T02:37:41Z 2012 2012 Thesis http://hdl.handle.net/10356/53732 en 156 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences
spellingShingle DRNTU::Science::Biological sciences
Nah, Giselle Sek Suan
The identification of cis-regulatory elements of runx3
description The RUNX3 gene is essential for the development of multiple cell lineages and is frequently involved in a variety of cancers and immunological diseases. Despite such frequent association with human diseases, the transcriptional regulation of Runx3 remains elusive. Owing to the huge ~350 kb Runx3 locus and complexity of the use of two alternate promoters for transcription, the search for regulatory regions outside the immediate promoters by traditional methods such as DNase I hypersensitive assay, proved to be a daunting task.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Nah, Giselle Sek Suan
format Theses and Dissertations
author Nah, Giselle Sek Suan
author_sort Nah, Giselle Sek Suan
title The identification of cis-regulatory elements of runx3
title_short The identification of cis-regulatory elements of runx3
title_full The identification of cis-regulatory elements of runx3
title_fullStr The identification of cis-regulatory elements of runx3
title_full_unstemmed The identification of cis-regulatory elements of runx3
title_sort identification of cis-regulatory elements of runx3
publishDate 2013
url http://hdl.handle.net/10356/53732
_version_ 1759856461518733312

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