Protein-protein interactions that mediate the role of AAA-ATPase p97/VCP/Cdc48 in protein aggregation and degradation
p97/VCP is a multifunctional AAA-ATPase that is directed into many different cellular processes by adaptor proteins that bind to it. With the use of SPR biosensor technology, we demonstrated the role of ATP binding to the D1 ATPase domain in p97/VCP in regulating adaptor protein competition between...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/54954 |
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| Institution: | Nanyang Technological University |
| Language: | English |