Cytotoxic triosmium carbonyl clusters : are proteins the target?

• المؤلف الرئيسي: Lee, Jia Ying
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Chemistry
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/55376
• المؤسسة: Nanyang Technological University

The interaction of the cytotoxic triosmium carbonyl cluster Os3(CO)10(NCMe)2, 1 with different amino acids and oligopeptides was examined with regard to its selectivity towards the different residues. It was found that 1 was reactive to cysteine, glutamic acid, aspartic acid, glutamine and asparagin...