Structural diversity of G-rich DNA : from telomeric G-quadruplexes to G-junction motifs

• Main Author: Lim, Kah Wai
• Other Authors: Phan Anh Tuan
• Format: Theses and Dissertations
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Biophysics; DRNTU::Science::Chemistry::Analytical chemistry::Nucleic acids; DRNTU::Science::Chemistry::Biochemistry::Spectroscopy
• Online Access: https://hdl.handle.net/10356/55392
• Institution: Nanyang Technological University

Four-stranded G-quadruplex DNA have been implicated in cellular processes and shown to exhibit important functional properties. In particular, putative quadruplex motifs were identified in important genomic loci including telomeres and oncogenic promoters, rendering them promising therapeutic target...