Synthesis and biological studies of benzofuran-based estrogen receptor α modulators, pyridone alkaloids and zanamivir

• Main Author: Leow, Min Li
• Other Authors: Liu Xuewei
• Format: Theses and Dissertations
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: http://hdl.handle.net/10356/55776
• Institution: Nanyang Technological University

In the first chapter, the search for new estrogen receptor alpha (ERα) modulators commenced with a trial molecular screening and 5,6-dihydroxybenzofuran was identified as a possible drug target for ERα. The target molecular modelling compound and a series of 5,6-dihydroxybenzofurans were synthesized...