The biosynthesis of vitamin E in the bacteria escherichia coli
The lipid antioxidant vitamin E is among the supplements essential for humans and animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and studied, cloned and expressed in order to enhance the vitamin E contents of producer crops. For decades, Escherichia coli has been...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2014
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| Online Access: | http://hdl.handle.net/10356/61685 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The lipid antioxidant vitamin E is among the supplements essential for humans and animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and studied, cloned and expressed in order to enhance the vitamin E contents of producer crops. For decades, Escherichia coli has been the primary workhorse for recombinant pharmaceuticals, especially for small molecules and proteins not requiring complex post-translational modifications. This work reviews the biosynthesis of tocochromanols, their functions, and past efforts in engineering the pathway, and the possibilities for E. coli as the optimal host system. |
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