The role of Mek/Erk signalling inhibition and Krüppel-like factor 2 in mouse ground state pluripotency

• المؤلف الرئيسي: Yeo, Jia Chi
• مؤلفون آخرون: Ng Huck Hui
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Biological sciences::Molecular biology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/62942
• المؤسسة: Nanyang Technological University

The maintenance of undifferentiated mouse embryonic stem cells (mESCs) requires the presence of LIF and serum. Interestingly, by using two chemical molecules to inhibit both the pro-differentiative Fgf/Mek/Erk and Gsk3/Tcf3 pathways in mESCs (dual inhibition or “2i”), a pluripotent “ground state”, r...