The role of Mek/Erk signalling inhibition and Krüppel-like factor 2 in mouse ground state pluripotency

The maintenance of undifferentiated mouse embryonic stem cells (mESCs) requires the presence of LIF and serum. Interestingly, by using two chemical molecules to inhibit both the pro-differentiative Fgf/Mek/Erk and Gsk3/Tcf3 pathways in mESCs (dual inhibition or “2i”), a pluripotent “ground state”, r...

Full description

Saved in:
Bibliographic Details
Main Author: Yeo, Jia Chi
Other Authors: Ng Huck Hui
Format: Theses and Dissertations
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/62942
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English

Similar Items