Study of Xist-mediated gene silencing using iXist

• Main Author: Tan, Jin Da
• Other Authors: Zhang Li Feng
• Format: Final Year Project
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/63463
• Institution: Nanyang Technological University

X Chromosome Inactivation (XCI) is an example of dosage compensation in mammals in which one of the X chromosomes in females is inactivated to balance the gene dosage between males and females. This process is dependent on a long non-coding RNA (lncRNA) called Xist. Previous report showed that Xist...