Validation of candidate genes involved in X chromosome inactivation

• Main Author: Lim, Zhong Ri
• Other Authors: Zhang Li Feng
• Format: Final Year Project
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/63613
• Institution: Nanyang Technological University

One of the two female X chromosomes is silenced in mammals to compensate for X-linked gene dosage. For over half a century, this process, known as X chromosome inactivation (XCI), has been studied intensively and Xist was found to have a central role in it. Although Xist RNA is critical for establis...