The biosynthesis of vitamin E in the bacteria Escherichia coli
The lipid antioxidant vitamin E is among the supplements essential for humans and animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and studied, cloned and expressed in order to enhance the vitamin E contents of producer crops. For decades, Escherichia coli has b...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/64419 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The lipid antioxidant vitamin E is among the supplements essential for humans and
animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and
studied, cloned and expressed in order to enhance the vitamin E contents of producer
crops. For decades, Escherichia coli has been the primary workhorse for recombinant
pharmaceuticals, especially for small molecules and proteins not requiring complex posttranslational
modifications. This work reviews the biosynthesis of tocochromanols, their
functions, and past efforts in engineering the pathway, and the possibilities for E. coli as
the optimal host system. |
|---|