Engineering cleavage efficient 2A peptides for enhancing monoclonal antibody expression in CHO cells
2A peptides are derived from various picorna viruses and are used to encode proteins in a single open-reading-frame (ORF). The polyprotein that is produced by the virus is cleaved co-translationally, through a “ribosomal-skipping” mechanism. 2A linked genes have been used in studies to co-express mu...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2015
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| Online Access: | http://hdl.handle.net/10356/64731 |
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| Institution: | Nanyang Technological University |
| Language: | English |