A structural hypothesis for the transition between bent and extended conformations of the leukocyte β2 integrins

• المؤلف الرئيسي: Shi, Minlong
• مؤلفون آخرون: Law Sai Kit, Alex
• التنسيق: Theses and Dissertations
• منشور في: 2008
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/6564

In this thesis, three fragments (PHE1, PHE2 and PHE3) of integrin beta2 subunit have been expressed and crystallized for structural and functional studies. The following solved crystal structures of the beta2 Genu in both bent (PHE2) and extended (PHE3) conformations provide a structural basis, repr...