Discovery of inhibitors of deubiquitinase USP21

• Main Author: Chua, Joanna Hui Xin
• Other Authors: Manoj N Krishnan
• Format: Final Year Project
• Language: English
• Published: 2016
• Subjects: DRNTU::Science; DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/67176
• Institution: Nanyang Technological University

Ubiquitination plays critical roles in several cellular processes, and are hence potential therapeutic targets against several debilitating human diseases, including cancers. Among various components of the ubiquitin-proteasome system, the deubiquitinases, the enzymes that remove ubiquitin modificat...