Defining gene signature underlying impaired hippocampal neurogenesis in triple transgenic Alzheimer’s disease mice
Using triple-transgenic (3xTg) Alzheimer’s disease (AD) mouse model that carries mutations in APP, p-Tau and PS1, we provided evidence to show that soluble Aβ and APP are accumulated in the hippocampus of AD mice by 1.5 months of age. In addition, impaired neurogenesis was also detected in the denta...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2016
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| Online Access: | http://hdl.handle.net/10356/67361 |
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| Institution: | Nanyang Technological University |
| Language: | English |