Defining gene signature underlying impaired hippocampal neurogenesis in triple transgenic Alzheimer’s disease mice

• Main Author: Ng, Yi Lin
• Other Authors: Zeng Li
• Format: Final Year Project
• Language: English
• Published: 2016
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/67361
• Institution: Nanyang Technological University

Using triple-transgenic (3xTg) Alzheimer’s disease (AD) mouse model that carries mutations in APP, p-Tau and PS1, we provided evidence to show that soluble Aβ and APP are accumulated in the hippocampus of AD mice by 1.5 months of age. In addition, impaired neurogenesis was also detected in the denta...