Mechanism underlying PTBP1-mediated alternative pre-mRNA splicing in regulating tissue-specific gene expression

• المؤلف الرئيسي: Muhammad Fursham Hamid
• مؤلفون آخرون: Eugene Makeyev
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2016
• الموضوعات: DRNTU::Science::Biological sciences::Molecular biology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/69374
• المؤسسة: Nanyang Technological University

Alternative pre-mRNA splicing (AS) provides an efficient means for diversifying the proteome and regulating gene expression levels in the higher eukaryotes. The gene regulation function often involves coupling between AS and nonsense-mediated decay (NMD), a cytoplasmic surveillance mechanism destabi...