Mechanism underlying PTBP1-mediated alternative pre-mRNA splicing in regulating tissue-specific gene expression

Alternative pre-mRNA splicing (AS) provides an efficient means for diversifying the proteome and regulating gene expression levels in the higher eukaryotes. The gene regulation function often involves coupling between AS and nonsense-mediated decay (NMD), a cytoplasmic surveillance mechanism destabi...

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Bibliographic Details
Main Author: Muhammad Fursham Hamid
Other Authors: Eugene Makeyev
Format: Theses and Dissertations
Language:English
Published: 2016
Subjects:
Online Access:https://hdl.handle.net/10356/69374
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Institution: Nanyang Technological University
Language: English
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