Characterization of regulatory mechanisms for BIM exon 3 alternative splicing

• Main Author: Bhadra, Malini
• Other Authors: Francesc Xavier Roca Castella
• Format: Theses and Dissertations
• Language: English
• Published: 2017
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/69548
• Institution: Nanyang Technological University

BCL-2-interacting mediator of cell death (BIM) is a proapoptotic member of the BCL-2 protein family. BIM upregulation is required for tyrosine kinase inhibitor (TKI)-mediated cell death in many kinase-driven cancers including chronic myeloid leukemia (CML) and epidermal growth factor receptor mutate...