Development of a FRET-based 3D in vitro breast tumor model and its application in evaluating drug-induced apoptosis

• Main Author: Anand, Padmaja
• Other Authors: Teoh Swee Hin
• Format: Theses and Dissertations
• Language: English
• Published: 2017
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/70579
• Institution: Nanyang Technological University

Tumorigenesis is a dynamic process involving growth, proliferation, heterotypic cell-cell and cell-ECM interactions and migration. Having traditionally relied on two-dimensional (2D) cultures for cancer research, it has been well-proven that these systems are unable to recapitulate the complexity an...