Cyclisation reactions for the synthesis of natural and unnatural piperidines

• Main Author: Barat, Viktor
• Other Authors: Roderick Wayland Bates
• Format: Theses and Dissertations
• Language: English
• Published: 2017
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis; DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
• Online Access: http://hdl.handle.net/10356/72882
• Institution: Nanyang Technological University

This work describes the platinum mediated ring opening isomerisation of 2,3-cyclopropanated piperidines, which results in either an endo or exocyclic olefin product. In the case where the beta-hydrogen is absent, a platinum-mediated Wagner-Meerwein type 1,2-alkyl shift reaction is observed. A sere...