The hidden rule in argonaute protein loading : sequence specificity

Argonaute (AGO) proteins play an important role in gene regulation with small RNAs serving as guides to targets. The small RNA duplex structure and 5’ terminal nucleotide are the only known determinants of AGO loading efficacy, and AGOs are believed to load small RNAs independently of their sequence...

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Bibliographic Details
Main Author: Goh, Eling
Other Authors: Katsutomo Okamura
Format: Theses and Dissertations
Language:English
Published: 2018
Subjects:
Online Access:http://hdl.handle.net/10356/73227
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Institution: Nanyang Technological University
Language: English