The cellular thermal shift assay : a novel strategy to study drug target engagement and resistance development in cancer therapy

• Main Author: Usha Sreekumar Lekshmy Kunjamma
• Other Authors: Par Nordlund
• Format: Theses and Dissertations
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
• Online Access: http://hdl.handle.net/10356/73363
• Institution: Nanyang Technological University

The drug binding to its target molecule determines the efficacy of therapeutics. Therefore, it is important to study drug target engagement in cells. This is often difficult because drug binding cannot be directly measured inside cells. We have developed a technique called cellular thermal shift ass...