The cellular thermal shift assay : a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies
A drug must engage its intended target to achieve its therapeutic effect. However, conclusively measuring target engagement (TE) in situ is challenging. This complicates preclinical development and is considered a key factor in the high rate of attrition in clinical trials. Here, we discuss a recent...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/87807 http://hdl.handle.net/10220/46848 |
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| Institution: | Nanyang Technological University |
| Language: | English |