The cellular thermal shift assay : a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies

• Main Authors: Martinez Molina, Daniel, Nordlund, Pär
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences; Mechanistic Biomarkers; Target Engagement
• Online Access: https://hdl.handle.net/10356/87807; http://hdl.handle.net/10220/46848
• Institution: Nanyang Technological University

A drug must engage its intended target to achieve its therapeutic effect. However, conclusively measuring target engagement (TE) in situ is challenging. This complicates preclinical development and is considered a key factor in the high rate of attrition in clinical trials. Here, we discuss a recent...