Sirolimus liposomal formulations : effects of Lipid Saturation/Surface charge on formulation stability and kinetics

Sirolimus is a macrolide compound commonly used as an anti-proliferant, as a result of its inhibitory effect on the mTOR pathway. Despite its therapeutic potential, its application remains limited due to its low water solubility, low stability and reduced bioavailability within the body. Since the d...

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Bibliographic Details
Main Author: Ong, Kelly Shi Hui
Other Authors: Subbu S. Venkatraman
Format: Final Year Project
Language:English
Published: 2018
Subjects:
Online Access:http://hdl.handle.net/10356/73739
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Institution: Nanyang Technological University
Language: English