Characterization of the splicing function of pseudouridine Ψ5 in U1 small nuclear RNA

• Main Author: Yong, Jing Yen
• Other Authors: Francesc Xavier Roca Castella
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/74455
• Institution: Nanyang Technological University

Pseudouridine (Ψ) is the major post-transcriptionally modified nucleotide in RNA. The 5’ end of U1 snRNA contains two evolutionarily conserved pseudouridines, Ψ5 and Ψ6, yet, their role in recognition of thousands of 5’ss variants remains to be established. Therefore, in our study, we investigated t...