CRISPR-Cas9 induced knockout for the functional study of Myef2’s role in X-chromosome inactivation

• Main Author: Cai, Derek Yaolong
• Other Authors: Zhang Li-Feng
• Format: Final Year Project
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences::Molecular biology; DRNTU::Science::Biological sciences::Genetics
• Online Access: http://hdl.handle.net/10356/74570
• Institution: Nanyang Technological University

Across animals of all kinds there are many different forms of dosage compensation in order to equalize gene expression between the sexes. One widely known form is known as X chromosome inactivation (XCI). In this process females compensate for their extra X chromosome by randomly choosing one to be...