Optimizing the synthesis of teixobactin and investigating the effects of cationicity of the macrocyclic pharmocophore on antibacterial activity

• Main Author: Ng, Belle Min Yee
• Other Authors: Liu Chuan Fa
• Format: Final Year Project
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/77124
• Institution: Nanyang Technological University

Following the widespread use and abuse of antibiotics, bacteria have evolved a diverse array of strategies to evade elimination by these antimicrobial drugs, a phenomenon commonly known as antibiotic resistance. The capacity for bacteria to develop resistance against multiple types of antibiotics p...