Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoy...

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Main Authors: Lee, Wei Li, Wee, Peixin, Nugraha, Chandra, Loo, Say Chye Joachim
其他作者: School of Materials Science & Engineering
格式: Article
語言:English
出版: 2013
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在線閱讀:https://hdl.handle.net/10356/79323
http://hdl.handle.net/10220/16451
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機構: Nanyang Technological University
語言: English
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總結:Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.